The Project


Biomimetic nanostructures 3D scaffolds for bone regeneration: Control of osteogenesis and angiogenesis through physicochemical stimuli

One of the biggest challenges in the construction of large tissue implants is the difficulty of developing permeable scaffolds for the transport of nutrients and waste, and spatial distribution of cells with high density and viability. Modern manufacturing techniques make it possible to reproduce the inherent structural features of tissues and to control the flow of nutrients to the scaffold by controlling parameters such as porosity, pore size and interconnection. Successful bone regeneration also requires sufficient rigidity for mechanical support and stability, and at the same time adequate flexibility for mechanical stimulation of cells.

BioBon3D inspires to develop hybrid nanocomposite scaffolds which, morphologically and structurally, will mimic the natural extracellular space.

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The project objectives are:

Objective 1

The development of functional biomimetic nanocomposite scaffolds with a structure that combines mechanical stiffness with the appropriate characteristics of porosity, to achieve the optimal environment for cell growth and differentiation.

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Objective 2

The process of “loading” biological agents to achieve acceleration of the osteogenetic and angiogenetic process.



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Objective 3

The comprehensive evaluation of the osteogenetic and angiogenic capacity of scaffolding, combining experimental in-vivo, in-vitro and computational techniques.


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Goals and objectives of the BioBon3D Project

Methodological Implementation

Based on the progress made to date, BioBon3D inspires to manufacture nanocomposite 3D scaffolds, reinforced with CNP (CNTs or GNPs or GO), with the product innovation consisting of:

(a) Creation of third generation scaffolds that will be osteoinductive and have appropriate mechanical and structural characteristics.

(b) Development and introduction of modern electrofibrillation and 3D printing techniques for the creation of 3D nanocomposite scaffolds with controlled stiffness.

 (c) New CS coupling techniques in CNPs, to achieve homogeneity in the dispersion of mixtures for the construction of scaffolding.

(d) “Loading” growth factors and antibodies on the scaffold and co-culture cells for osteogenesis and angiogenesis.

(e) Modeling of the scaffold structure and regenerative processes.

(f) Combination of experimental and numerical methods for its evaluation.

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